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By Huuk Team

Road trip from Knoxville to Durham

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Show more (4+)

ITINERARY

6h 32m345 miles21 stops
1
Craggy Mountain Line
111 N Woodfin Ave, Asheville, NC 28804-8818
2
Peter Kern Library
407 Union Ave, Knoxville, TN 37902-2112
Hidden inside the historic Kern Building, behind The Oliver Hotel lobby, is Knoxville’s one and only speakeasy, The Peter Kern Library. Once a well-kept secret, the bar is now a beloved institution. The dark wood, fireplace, rows of books, and cocktails named after literary characters create a warm and cozy atmosphere where time seems to stop.
3
Game On Escapes & More
107 Edinburgh South Dr Suite 203, Cary, NC 27511-8426
We offer family friendly escape games and a game show appealing to a variety of ages. Great for corporate events, team outings, and just a fun night out with friends and family.
4
Krutch Park
504 Market St, Knoxville, TN 37902-2107
5
Knoxville Botanical Garden
2743 Wimpole Ave, Knoxville, TN 37914-5958
6
Muse Knoxville
516 N Beaman St, Knoxville, TN 37914-4410
Muse Knoxville is a children’s Science, Technology, Engineering, Arts, & Math (STEAM) museum located in Chilhowee Park. Our programs in the museum, in schools across East Tennessee, & throughout Knoxville bring STEM, the arts, health & wellness, & emergent literacy to life in the minds of children. We inspire & empower ALL children through transformative learning experiences through a variety of hands-on and inquiry-based, exhibits and Outreach programs for children aged 6 mos. to 10 y/o. *Museum Play - Indoor educational learning & play spaces, a full-dome planetarium, outdoor learning spaces & a playground! *Field Trips - Bring your class, homeschool, daycare or youth group for a day of fun! *Parties/Events - Choose from a variety of packages to celebrate your special day with us. *Planetarium - We house East Tennessee's only public-access planetarium with shows that rotate every hour!
7
Cathedral of the Most Sacred Heart of Jesus
711 S Northshore Dr, Knoxville, TN 37919-7593
8
Iron Heart Winery
3742 Boone Furnace Rd, Allisonia, VA 24347-4001
9
Historic Bethania, NC
5393 Ham Horton Lane Bethania, NC, Winston Salem, NC 27010
10
JDL Fast Track
2505 Empire Dr, Winston Salem, NC 27103-6709
11
Hanes Mall
3320 Silas Creek Pkwy, Winston Salem, NC 27103-3031
Hanes Mall features favorite stores such as Belk, Dillard's, Macy's, JCPenney, Sears, and Old Navy as well as specialty shops like American Eagle, Abercrombie & Fitch, Gymboree and Banana Republic.
12
European Touch
116 Reynolda Vlg, Winston Salem, NC 27106-5123
13
Reynolda House Museum of American Art
2250 Reynolda Rd, Winston Salem, NC 27106-5117
Nestled within 180 acres adjacent to Wake Forest University, Reynolda is the perfect place to escape and discover art, nature, history, and so much more. View Reynolda’s world-renowned American art collection and curated exhibitions on display throughout the interiors of Katharine and R.J. Reynolds’s 1917 bungalow and in the Babcock Gallery. Plus, learn about the Reynolds family, Katharine’s vision, and the history of the estate. After touring the Museum, embrace the outdoors in the Gardens and grounds, which are always free and open to the public year-round from sunrise to sunset. Do flowers make you hungry? Make your way to Reynolda Village to shop and dine.
14
Lam Museum of Anthropology, Wake Forest University
Palmer Hall, Carroll Weathers Drive, Winston Salem, NC 27109
Discover North Carolina's only museum dedicated to the study of global cultures. Explore stories of humanity, from ancient archaeological sites to the celebrations and struggles of today. Learn about peoples around the world through their everyday and ceremonial objects, and visual arts. Changing exhibits highlight the Museum's collections of nearly 30,000 archaeological and ethnographic artifacts from more than 350 cultures and 90 countries. Admission is free.
15
Grand 18-Winston-Salem
5601 University Pkwy, Winston Salem, NC 27105-1313
16
Recreation Billiards
412 W 4th St, Winston Salem, NC 27101-2805
17
Salem Lake
1001 Salem Lake Rd, Winston Salem, NC 27107-1571
18
Center City Park
200 N Elm St, Greensboro, NC 27401-2402
19
Forest Oaks Country Club
4600 Forest Oaks Dr, Greensboro, NC 27406-9313
20
The Raleigh Market
1025 Blue Ridge Rd, Raleigh, NC 27607-3902
Located on the historic N.C. State Fairgrounds, The Raleigh Market is recognized as one of the Top 10 flea markets in the U.S. Each weekend, indoor and outdoor vendors showcase vintage goods and antiques, collectibles, new items, thrift items, crafts, art, jewelry and so much more. Food trucks, farm stands and fair food ensure customers do not leave hungry! The Raleigh Market is open Saturdays and Sundays, 9 am - 5 pm. Admission and parking are free.
21
North Carolina Museum of History
5 E Edenton St, Raleigh, NC 27601-1011
Explore more than 14,000 years of North Carolina history, from the state's earliest inhabitants through the 20th century. The major exhibition The Story of North Carolina features fascinating artifacts, multimedia presentations, and an interactive format for all ages. Other exhibits highlight the state's military history, sports heroes, decorative arts and more. Monthly programs include children's programs, craft demonstrations and family events. The Museum Shop, featuring North Carolina crafts, and the on-site restaurant Pharaoh's at the Museum are open daily. Admission is free, although some special exhibits require a fee. Free parking is available on weekends in the Jones/Edenton Street lot. Museum hours are Monday through Saturday, 9 a.m. to 5 p.m., and Sunday, noon to 5 p.m.
Customize this Trip

OVERVIEW

1
Start:Craggy Mountain Line
Asheville, North Carolina·
4.5
(9) review
111 N Woodfin Ave, Asheville, NC 28804-8818
2
Peter Kern Library
Knoxville, Tennessee·
4.0
(99) review
Hidden inside the historic Kern Building, behind The Oliver Hotel lobby, is Knoxville’s one and only speakeasy, The Peter Kern Library. Once a well-kept secret, the bar is now a beloved institution. The dark wood, fireplace, rows of books, and cocktails named after literary characters create a warm and cozy atmosphere where time seems to stop.
407 Union Ave, Knoxville, TN 37902-2112
3
Game On Escapes & More
Cary, North Carolina·
5.0
(98) review
We offer family friendly escape games and a game show appealing to a variety of ages. Great for corporate events, team outings, and just a fun night out with friends and family.
107 Edinburgh South Dr Suite 203, Cary, NC 27511-8426
4
Krutch Park
Knoxville, Tennessee·
4.5
(90) review
504 Market St, Knoxville, TN 37902-2107
5
Knoxville Botanical Garden
Knoxville, Tennessee·
3.5
(97) review
2743 Wimpole Ave, Knoxville, TN 37914-5958
6
Muse Knoxville
Knoxville, Tennessee·
4.0
(91) review
Muse Knoxville is a children’s Science, Technology, Engineering, Arts, & Math (STEAM) museum located in Chilhowee Park. Our programs in the museum, in schools across East Tennessee, & throughout Knoxville bring STEM, the arts, health & wellness, & emergent literacy to life in the minds of children. We inspire & empower ALL children through transformative learning experiences through a variety of hands-on and inquiry-based, exhibits and Outreach programs for children aged 6 mos. to 10 y/o. *Museum Play - Indoor educational learning & play spaces, a full-dome planetarium, outdoor learning spaces & a playground! *Field Trips - Bring your class, homeschool, daycare or youth group for a day of fun! *Parties/Events - Choose from a variety of packages to celebrate your special day with us. *Planetarium - We house East Tennessee's only public-access planetarium with shows that rotate every hour!
516 N Beaman St, Knoxville, TN 37914-4410
7
Cathedral of the Most Sacred Heart of Jesus
Knoxville, Tennessee·
4.5
(9) review
711 S Northshore Dr, Knoxville, TN 37919-7593
8
Iron Heart Winery
Allisonia, Virginia·
4.0
(7) review
3742 Boone Furnace Rd, Allisonia, VA 24347-4001
9
Historic Bethania, NC
Winston Salem, North Carolina·
4.0
(46) review
5393 Ham Horton Lane Bethania, NC, Winston Salem, NC 27010
10
JDL Fast Track
Winston Salem, North Carolina·
4.0
(9) review
2505 Empire Dr, Winston Salem, NC 27103-6709
11
Hanes Mall
Winston Salem, North Carolina·
4.0
(85) review
Hanes Mall features favorite stores such as Belk, Dillard's, Macy's, JCPenney, Sears, and Old Navy as well as specialty shops like American Eagle, Abercrombie & Fitch, Gymboree and Banana Republic.
3320 Silas Creek Pkwy, Winston Salem, NC 27103-3031
12
European Touch
Winston Salem, North Carolina·
5.0
(5) review
116 Reynolda Vlg, Winston Salem, NC 27106-5123
13
Reynolda House Museum of American Art
Winston Salem, North Carolina·
4.5
(659) review
Nestled within 180 acres adjacent to Wake Forest University, Reynolda is the perfect place to escape and discover art, nature, history, and so much more. View Reynolda’s world-renowned American art collection and curated exhibitions on display throughout the interiors of Katharine and R.J. Reynolds’s 1917 bungalow and in the Babcock Gallery. Plus, learn about the Reynolds family, Katharine’s vision, and the history of the estate. After touring the Museum, embrace the outdoors in the Gardens and grounds, which are always free and open to the public year-round from sunrise to sunset. Do flowers make you hungry? Make your way to Reynolda Village to shop and dine.
2250 Reynolda Rd, Winston Salem, NC 27106-5117
14
Lam Museum of Anthropology, Wake Forest University
Winston Salem, North Carolina·
4.0
(9) review
Discover North Carolina's only museum dedicated to the study of global cultures. Explore stories of humanity, from ancient archaeological sites to the celebrations and struggles of today. Learn about peoples around the world through their everyday and ceremonial objects, and visual arts. Changing exhibits highlight the Museum's collections of nearly 30,000 archaeological and ethnographic artifacts from more than 350 cultures and 90 countries. Admission is free.
Palmer Hall, Carroll Weathers Drive, Winston Salem, NC 27109
15
Grand 18-Winston-Salem
Winston Salem, North Carolina·
4.0
(72) review
5601 University Pkwy, Winston Salem, NC 27105-1313
16
Recreation Billiards
Winston Salem, North Carolina·
4.0
(9) review
412 W 4th St, Winston Salem, NC 27101-2805
17
Salem Lake
Winston Salem, North Carolina·
4.5
(97) review
1001 Salem Lake Rd, Winston Salem, NC 27107-1571
18
Center City Park
Greensboro, North Carolina·
4.5
(9) review
200 N Elm St, Greensboro, NC 27401-2402
19
Forest Oaks Country Club
Greensboro, North Carolina·
4.0
(9) review
4600 Forest Oaks Dr, Greensboro, NC 27406-9313
20
The Raleigh Market
Raleigh, North Carolina·
4.0
(96) review
Located on the historic N.C. State Fairgrounds, The Raleigh Market is recognized as one of the Top 10 flea markets in the U.S. Each weekend, indoor and outdoor vendors showcase vintage goods and antiques, collectibles, new items, thrift items, crafts, art, jewelry and so much more. Food trucks, farm stands and fair food ensure customers do not leave hungry! The Raleigh Market is open Saturdays and Sundays, 9 am - 5 pm. Admission and parking are free.
1025 Blue Ridge Rd, Raleigh, NC 27607-3902
21
North Carolina Museum of History
Raleigh, North Carolina·
4.5
(936) review
Explore more than 14,000 years of North Carolina history, from the state's earliest inhabitants through the 20th century. The major exhibition The Story of North Carolina features fascinating artifacts, multimedia presentations, and an interactive format for all ages. Other exhibits highlight the state's military history, sports heroes, decorative arts and more. Monthly programs include children's programs, craft demonstrations and family events. The Museum Shop, featuring North Carolina crafts, and the on-site restaurant Pharaoh's at the Museum are open daily. Admission is free, although some special exhibits require a fee. Free parking is available on weekends in the Jones/Edenton Street lot. Museum hours are Monday through Saturday, 9 a.m. to 5 p.m., and Sunday, noon to 5 p.m.
5 E Edenton St, Raleigh, NC 27601-1011

CHECKLIST

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FAQ
Frequently Asked Questions
What's the driving distance between Knoxville and Durham?
The distance is 345 miles
What's the travel time between Knoxville and Durham?
The driving time can vary depending on traffic conditions, but it is typically 6h 32m mins in normal traffic
What are some of the best cities to visit between Knoxville and Durham?
Some popular stops include
Are there any cool sights or attractions I shouldn't miss on my drive to Durham?
There are plenty! Here are some stops you shouldn’t miss on your way to Durham
What’s the weather like in Durham?
The weather in Durham is generally mild year-round, with warm, dry summers and cool, wet winters. See the links below for more information
Weather in Durham in January
Weather in Durham in February
Weather in Durham in March
Weather in Durham in April
Weather in Durham in May
Weather in Durham in June
Weather in Durham in July
Weather in Durham in August
Weather in Durham in September
Weather in Durham in October
Weather in Durham in November
Weather in Durham in December
Interested in a detailed plan for your time in Durham?
Plan your dream Durham trip with our daily itineraries featuring must-see attractions! See them here!
A 1-day itinerary in Durham
A 2-day itinerary in Durham
A 3-day itinerary in Durham
A 4-day itinerary in Durham
A 5-day itinerary in Durham
A 6-day itinerary in Durham
Where else can I travel to if I'm starting my trip in Knoxville?
We have a lot of great trip options for Knoxville! See the links below for all the itineraries we created for you