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By Huuk Team

Road trip from Buffalo to Sioux Falls

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ITINERARY

20h 51m1,116 miles17 stops
1
The Buffalo History Museum
1 Museum Ct, Buffalo, NY 14216-3160
2
Inniskillin Wines
1499 Line 3, Niagara-on-the-Lake, Ontario L0S 1J0 Canada
Many of those who appreciate and collect wine have discovered that a journey to the heart of wine country adds an indescribable dimension to the appreciation of the distinctiveness of each fine wine. In that spirit, Inniskillin invites you to fully experience our full VQA portfolio in Niagara-on-the-Lake. Experience firsthand the full range of our premium wines while enjoying spectacular sights, regional culinary specialties and outstanding hospitality in one of Canada's great natural treasures, the Niagara Peninsula. We look forward to toasting your arrival!
3
Presque Isle Downs & Casino
8199 Perry Hwy, Erie, PA 16509-6640
Presque Isle Downs & Casino is your best bet for gaming excitement! With over 1,500 of the hottest slots, you'll find a thrilling new game to spin every time you play. Prefer tables? You're in luck! Come try your hand at any of our over 30 thrilling table games. Like to bet on sports? Get in the game at our TwinSpires Sportsbook! With convenient sports betting kiosks, wagering is quick and easy so you'll never miss a minute of the action. Plus, catch seasonal live thoroughbred horse racing at our track! While you're here be sure to sign up for our Players Club. All new members get up to $2,500 free slot play or $25 in guaranteed match play right out of the gate! It's fast and free to join. Every time you play with your Players Club card you'll earn valuable reward points that qualify you to enjoy members-only promotions, perks, exclusive offers and much more! Presque Isle Downs & Casino is located in Erie, PA, just off of I-90 at Exit 27. Gambling Problem? Call 1-800 GAMBLER.
4
Museum of Contemporary Art Cleveland
11400 Euclid Ave, Cleveland, OH 44106-3926
5
Rock & Roll Hall of Fame
1100 Rock and Roll Blvd Main Terminal, Cleveland, OH 44114-1023
Headquartered in a boldly designed building on Lake Erie's shore, The Rock and Roll Hall of Fame is a 150,000-square-foot museum featuring ever-changing exhibits documenting the history of rock and roll, from Elvis to our days. You’ll see hundreds of original artifacts, from Jimi Hendrix outfits to The Beatles’ handwritten lyrics. Experience the excitement of a Rock Hall induction night at the Power of Rock Experience or have your very own jam session at the Garage. You can also watch a concert while you're here, so check out the Rock Hall’s schedule and plan ahead. – Tripadvisor
6
Federal Reserve Bank of Cleveland: Education and Learning Center
1455 E 6th St, Cleveland, OH 44114-2517
Ever wonder how money works or what the Federal Reserve Bank of Cleveland does as part of the central bank of the US? Visit our Education and Learning Center featuring more than 25 fun, hands-on exhibits that answer these questions and more! We have interactive games, visual exhibits, creative stations, and illuminating films that explain everything about money you can think of, from how we use it, to why it looks the way it looks. Come see our historic lobby, take pictures with our money tree, trade coconuts on Barter Island, identify counterfeit bills, and even make your own money! All this in the heart of Cleveland, just steps away from downtown attractions. Admission is free and photos are welcome.
7
Lock 3
200 S Main St, Akron, OH 44308-1315
8
Sprucewood Shores Estate Winery
7258 Cty Rd, 50 West, Harrow, Essex, Ontario N0R 1G0 Canada
The Sprucewood Family warmly welcomes you to sample handcrafted 100% Ontario VQA wines at Ontario's only beachfront destination vineyard, winery and tasting room. We are situated on 45 Acres with access to gardens, a sandy beach, and picnic tables. Enjoy a glass of wine with a picnic basket and explore our grounds year round. Tasting room open 7 days a week 11am - 5pm (we occasionally close early due to special events. Please check our social media for daily updates @sprucewoodshores)
9
Allen County War Memorial Coliseum
4000 Parnell Ave, Fort Wayne, IN 46805-1414
10
Michigan Avenue Bridge
333 Michigan Ave, Chicago, IL 60601-3901
The view from the bridge is one of the best vistas the city has to offer.
11
Boystown
Chicago, IL
Located in Chicago's North Side, this vibrant neighborhood is known for its exciting nightlife and for being one of the largest LGBTQIA+ communities in the city. It's the host of the annual Chicago Pride Parade, and a must-see in the area is the Legacy Walk on Halsted Street, where you can learn about the contributions of the LGBTQIA+ community while admiring the colorful street art and rainbow crosswalks. Check out the unique shops and then grab a bite at one of the area's delicious Thai or Mexican restaurants. At night, visit one of the neighborhood's bars to enjoy a drag show, concert, and tasty cocktail. Consider taking a food or walking tour of Chicago that stops by Boystown. – Tripadvisor
12
Wrigley Field
1060 W. Addison St., Chicago, IL 60613-4566
Get a behind-the-scenes look at the legendary home of the Chicago Cubs with Wrigley Field Tours. Built in 1914, this must-see Chicago attraction houses more than 100 years of history. New this year, fans can join us on a non-gameday Ivy Tour which includes the opportunity to take a photo in front of Wrigley Field’s historic ivy wall.
13
Alliant Energy Center
1919 Alliant Energy Center Way, Madison, WI 53713-1400
Our premier downtown multi-venue complex features four unique and versatile venues: Veterans Memorial Coliseum, Exhibition Hall, the New Holland Pavilions, and Willow Island. A top choice for expositions, conventions, meetings, concerts, sporting events, ag events, and much more, the Alliant Energy Center complex is a one-stop-shop for all your events. Ample parking, mouthwatering catering, dedicated staff, and a full range of rental equipment & high speed internet make AEC an event planners delight!
14
First Unitarian Meeting House of Madison
900 University Bay Dr, Madison, WI 53705-2298
15
Stockyards Ag Experience
301 E Falls Park Dr Main Entrance is on the South side of the building., Sioux Falls, SD 57104-5962
We deepen the connection between agriculture to everyday life with learning experiences that highlight history, science, culture and economic impact. We educate through interactive displays, hands-on learning and vibrant stories.
16
Stogeez Cigar Lounge
201 E 11th St, Sioux Falls, SD 57104-6748
17
Little Wine Cellar Co
2390 S Louise Ave, Sioux Falls, SD 57106-4337
Customize this Trip

OVERVIEW

1
Start:The Buffalo History Museum
Buffalo, Erie County, New York·
4.0
(97) review
1 Museum Ct, Buffalo, NY 14216-3160
2
Inniskillin Wines
Niagara-on-the-Lake, Ontario·
4.5
(969) review
Many of those who appreciate and collect wine have discovered that a journey to the heart of wine country adds an indescribable dimension to the appreciation of the distinctiveness of each fine wine. In that spirit, Inniskillin invites you to fully experience our full VQA portfolio in Niagara-on-the-Lake. Experience firsthand the full range of our premium wines while enjoying spectacular sights, regional culinary specialties and outstanding hospitality in one of Canada's great natural treasures, the Niagara Peninsula. We look forward to toasting your arrival!
1499 Line 3, Niagara-on-the-Lake, Ontario L0S 1J0 Canada
3
Presque Isle Downs & Casino
Erie, Pennsylvania·
3.5
(981) review
Presque Isle Downs & Casino is your best bet for gaming excitement! With over 1,500 of the hottest slots, you'll find a thrilling new game to spin every time you play. Prefer tables? You're in luck! Come try your hand at any of our over 30 thrilling table games. Like to bet on sports? Get in the game at our TwinSpires Sportsbook! With convenient sports betting kiosks, wagering is quick and easy so you'll never miss a minute of the action. Plus, catch seasonal live thoroughbred horse racing at our track! While you're here be sure to sign up for our Players Club. All new members get up to $2,500 free slot play or $25 in guaranteed match play right out of the gate! It's fast and free to join. Every time you play with your Players Club card you'll earn valuable reward points that qualify you to enjoy members-only promotions, perks, exclusive offers and much more! Presque Isle Downs & Casino is located in Erie, PA, just off of I-90 at Exit 27. Gambling Problem? Call 1-800 GAMBLER.
8199 Perry Hwy, Erie, PA 16509-6640
4
Museum of Contemporary Art Cleveland
Cleveland, Ohio·
3.5
(93) review
11400 Euclid Ave, Cleveland, OH 44106-3926
5
Rock & Roll Hall of Fame
Cleveland, Ohio·
4.5
(9964) review
Headquartered in a boldly designed building on Lake Erie's shore, The Rock and Roll Hall of Fame is a 150,000-square-foot museum featuring ever-changing exhibits documenting the history of rock and roll, from Elvis to our days. You’ll see hundreds of original artifacts, from Jimi Hendrix outfits to The Beatles’ handwritten lyrics. Experience the excitement of a Rock Hall induction night at the Power of Rock Experience or have your very own jam session at the Garage. You can also watch a concert while you're here, so check out the Rock Hall’s schedule and plan ahead. – Tripadvisor
1100 Rock and Roll Blvd Main Terminal, Cleveland, OH 44114-1023
6
Federal Reserve Bank of Cleveland: Education and Learning Center
Cleveland, Ohio·
4.5
(95) review
Ever wonder how money works or what the Federal Reserve Bank of Cleveland does as part of the central bank of the US? Visit our Education and Learning Center featuring more than 25 fun, hands-on exhibits that answer these questions and more! We have interactive games, visual exhibits, creative stations, and illuminating films that explain everything about money you can think of, from how we use it, to why it looks the way it looks. Come see our historic lobby, take pictures with our money tree, trade coconuts on Barter Island, identify counterfeit bills, and even make your own money! All this in the heart of Cleveland, just steps away from downtown attractions. Admission is free and photos are welcome.
1455 E 6th St, Cleveland, OH 44114-2517
7
Lock 3
Akron, Ohio·
4.5
(98) review
200 S Main St, Akron, OH 44308-1315
8
Sprucewood Shores Estate Winery
Harrow, Essex, Ontario·
4.5
(97) review
The Sprucewood Family warmly welcomes you to sample handcrafted 100% Ontario VQA wines at Ontario's only beachfront destination vineyard, winery and tasting room. We are situated on 45 Acres with access to gardens, a sandy beach, and picnic tables. Enjoy a glass of wine with a picnic basket and explore our grounds year round. Tasting room open 7 days a week 11am - 5pm (we occasionally close early due to special events. Please check our social media for daily updates @sprucewoodshores)
7258 Cty Rd, 50 West, Harrow, Essex, Ontario N0R 1G0 Canada
9
Allen County War Memorial Coliseum
Fort Wayne, Indiana·
4.0
(99) review
4000 Parnell Ave, Fort Wayne, IN 46805-1414
10
Michigan Avenue Bridge
Chicago, Illinois·
4.5
(985) review
The view from the bridge is one of the best vistas the city has to offer.
333 Michigan Ave, Chicago, IL 60601-3901
11
Boystown
Chicago, Illinois·
4.5
(98) review
Located in Chicago's North Side, this vibrant neighborhood is known for its exciting nightlife and for being one of the largest LGBTQIA+ communities in the city. It's the host of the annual Chicago Pride Parade, and a must-see in the area is the Legacy Walk on Halsted Street, where you can learn about the contributions of the LGBTQIA+ community while admiring the colorful street art and rainbow crosswalks. Check out the unique shops and then grab a bite at one of the area's delicious Thai or Mexican restaurants. At night, visit one of the neighborhood's bars to enjoy a drag show, concert, and tasty cocktail. Consider taking a food or walking tour of Chicago that stops by Boystown. – Tripadvisor
Chicago, IL
12
Wrigley Field
Chicago, Illinois·
4.5
(9953) review
Get a behind-the-scenes look at the legendary home of the Chicago Cubs with Wrigley Field Tours. Built in 1914, this must-see Chicago attraction houses more than 100 years of history. New this year, fans can join us on a non-gameday Ivy Tour which includes the opportunity to take a photo in front of Wrigley Field’s historic ivy wall.
1060 W. Addison St., Chicago, IL 60613-4566
13
Alliant Energy Center
Madison, Wisconsin·
4.0
(99) review
Our premier downtown multi-venue complex features four unique and versatile venues: Veterans Memorial Coliseum, Exhibition Hall, the New Holland Pavilions, and Willow Island. A top choice for expositions, conventions, meetings, concerts, sporting events, ag events, and much more, the Alliant Energy Center complex is a one-stop-shop for all your events. Ample parking, mouthwatering catering, dedicated staff, and a full range of rental equipment & high speed internet make AEC an event planners delight!
1919 Alliant Energy Center Way, Madison, WI 53713-1400
14
First Unitarian Meeting House of Madison
Madison, Wisconsin·
4.5
(96) review
900 University Bay Dr, Madison, WI 53705-2298
15
Stockyards Ag Experience
Sioux Falls, South Dakota·
4.5
(8) review
We deepen the connection between agriculture to everyday life with learning experiences that highlight history, science, culture and economic impact. We educate through interactive displays, hands-on learning and vibrant stories.
301 E Falls Park Dr Main Entrance is on the South side of the building., Sioux Falls, SD 57104-5962
16
Stogeez Cigar Lounge
Sioux Falls, South Dakota·
4.0
(8) review
201 E 11th St, Sioux Falls, SD 57104-6748
17
Little Wine Cellar Co
Sioux Falls, South Dakota·
5.0
(9) review
2390 S Louise Ave, Sioux Falls, SD 57106-4337

CHECKLIST

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FAQ
Frequently Asked Questions
What's the driving distance between Buffalo and Sioux Falls?
The distance is 1,116 miles
What's the travel time between Buffalo and Sioux Falls?
The driving time can vary depending on traffic conditions, but it is typically 20h 51m mins in normal traffic
What are some of the best cities to visit between Buffalo and Sioux Falls?
Some popular stops include
Are there any cool sights or attractions I shouldn't miss on my drive to Sioux Falls?
There are plenty! Here are some stops you shouldn’t miss on your way to Sioux Falls
What’s the weather like in Sioux Falls?
The weather in Sioux Falls is generally mild year-round, with warm, dry summers and cool, wet winters. See the links below for more information
Weather in Sioux Falls in January
Weather in Sioux Falls in February
Weather in Sioux Falls in March
Weather in Sioux Falls in April
Weather in Sioux Falls in May
Weather in Sioux Falls in June
Weather in Sioux Falls in July
Weather in Sioux Falls in August
Weather in Sioux Falls in September
Weather in Sioux Falls in October
Weather in Sioux Falls in November
Weather in Sioux Falls in December
Interested in a detailed plan for your time in Sioux Falls?
Plan your dream Sioux Falls trip with our daily itineraries featuring must-see attractions! See them here!
A 1-day itinerary in Sioux Falls
A 2-day itinerary in Sioux Falls
A 3-day itinerary in Sioux Falls
A 4-day itinerary in Sioux Falls
A 5-day itinerary in Sioux Falls
A 6-day itinerary in Sioux Falls
Where else can I travel to if I'm starting my trip in Buffalo?
We have a lot of great trip options for Buffalo! See the links below for all the itineraries we created for you