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By Huuk Team

Road trip from Buffalo to Myrtle Beach

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iconSpas & Wellness
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iconFood & Drink
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ITINERARY

16h 9m823 miles16 stops
1
The Buffalo History Museum
1 Museum Ct, Buffalo, NY 14216-3160
2
Inniskillin Wines
1499 Line 3, Niagara-on-the-Lake, Ontario L0S 1J0 Canada
Many of those who appreciate and collect wine have discovered that a journey to the heart of wine country adds an indescribable dimension to the appreciation of the distinctiveness of each fine wine. In that spirit, Inniskillin invites you to fully experience our full VQA portfolio in Niagara-on-the-Lake. Experience firsthand the full range of our premium wines while enjoying spectacular sights, regional culinary specialties and outstanding hospitality in one of Canada's great natural treasures, the Niagara Peninsula. We look forward to toasting your arrival!
3
Erie Bayfront Convention Center
1 Sassafras Pier, Erie, PA 16507-2011
4
Presque Isle Downs & Casino
8199 Perry Hwy, Erie, PA 16509-6640
Presque Isle Downs & Casino is your best bet for gaming excitement! With over 1,500 of the hottest slots, you'll find a thrilling new game to spin every time you play. Prefer tables? You're in luck! Come try your hand at any of our over 30 thrilling table games. Like to bet on sports? Get in the game at our TwinSpires Sportsbook! With convenient sports betting kiosks, wagering is quick and easy so you'll never miss a minute of the action. Plus, catch seasonal live thoroughbred horse racing at our track! While you're here be sure to sign up for our Players Club. All new members get up to $2,500 free slot play or $25 in guaranteed match play right out of the gate! It's fast and free to join. Every time you play with your Players Club card you'll earn valuable reward points that qualify you to enjoy members-only promotions, perks, exclusive offers and much more! Presque Isle Downs & Casino is located in Erie, PA, just off of I-90 at Exit 27. Gambling Problem? Call 1-800 GAMBLER.
5
Cathedral of Learning
4200 5th Ave., Pittsburgh, PA 15260
6
Point State Park
601 Commonwealth Pl Bldg A, Pittsburgh, PA 15222
Serving as a key strategic spot during the French and Indian War, this National Historic Landmark and park offer stunning views of the city and a variety of outdoor recreation.
7
Iron Heart Winery
3742 Boone Furnace Rd, Allisonia, VA 24347-4001
8
Grand 18-Winston-Salem
5601 University Pkwy, Winston Salem, NC 27105-1313
9
Lam Museum of Anthropology, Wake Forest University
Palmer Hall, Carroll Weathers Drive, Winston Salem, NC 27109
Discover North Carolina's only museum dedicated to the study of global cultures. Explore stories of humanity, from ancient archaeological sites to the celebrations and struggles of today. Learn about peoples around the world through their everyday and ceremonial objects, and visual arts. Changing exhibits highlight the Museum's collections of nearly 30,000 archaeological and ethnographic artifacts from more than 350 cultures and 90 countries. Admission is free.
10
Salem Lake
1001 Salem Lake Rd, Winston Salem, NC 27107-1571
11
Possum Trot Golf Club
Possum Trot Road, Myrtle Beach, SC 29582
Recommended course noted for exceptional service and playing conditions.
12
Myrtle Beach National
4900 National Dr, Myrtle Beach, SC 29579-7212
13
Tanger Outlets Myrtle Beach Hwy 17
10835 Kings Rd, Myrtle Beach, SC 29572-6076
Find great savings on merchandise from your favorite designer and name-brands direct from the manufacturer at stores like: Polo Ralph Lauren, Old Navy, Calvin Klein, Gap, Banana Republic, Ann Taylor, Kate Spade, Lucky Brand Jeans, Coach, Tommy Hilfiger and many more. Before you travel, check out the Tanger Outlet website to find the latest Coupons & Sales Offers for Tanger Outlets in Myrtle Beach. Or, when you arrive at the outlets, make your first stop Shopper Services to learn about the benefits of joining TangerClub (Tanger Club information is also available online). In Shopper Services you can purchase a coupon book full of great savings or if you are already a TangerClub member pick up a coupon book for free! Think Outlets, Think Tanger.
14
Magoo's Sports & Spirits
3308 Waccamaw Blvd, Myrtle Beach, SC 29579-9464
Magoo's Sports & Spirits has been a Myrtle Beach neighborhood sports bar since 1995. Magoo's features an expansive mahogany central bar and plays all sports, all the time, from 24 televisions - not to mention steel and electronic darts, pool, and a host of games. Famous for the best chicken wings in Myrtle Beach and out-of-this-world burgers, Magoo expanded the menu for their new location to include paninis, seafood baskets, and sweet potato fries. Join us for our weekly events! -Taco Tuesday: Get two tacos for $5. Tequila and vodka drinks are $2.50 after 9 pm -Trivia Thursday: Starts at 6 pm. Prizes for winner! -Friday Soft Tip Dart Tournament: Sign-ups start at 6 pm and darts fly at 7:30 pm
15
The Simpsons in 4D
1199 Celebrity Cir Broadway at the Beach, Myrtle Beach, SC 29577
Established in 2018. The Simpsons in 4D is a fully-themed cinematic attraction located at Broadway at the Beach in Myrtle Beach, South Carolina. Follow @Si4D.Simpsons4D on Instagram and Facebook for updates! The Simpsons in 4D delivers a slice of Springfield with the famous Aztec Theater and Kwik-E-Mart from the groundbreaking television show. The Aztec Theater features a themed lobby experience and a 4D Experience starring Homer and his family. This exciting animated special effects experience with 4D motion seats follows The Simpsons on a fun-filled immersive adventure. Shows run every 15 minutes. The Aztec Theater is a ticketed experience that also includes a souvenir red carpet photo with The Simpsons. Next door, guests can explore and shop at the iconic Kwik-E-Mart The convenience store has been brought to life with select products, including Buzz Soda, Lard Lad Donuts and six show-inspired Squishee flavors, as well as a wide array of custom The Simpsons branded merchandise.
16
X Gym Sports Mall
568 George Bishop Pkwy near 501 and 17 Highway, Myrtle Beach, SC 29579-7339
Customize this Trip

OVERVIEW

1
Start:The Buffalo History Museum
Buffalo, Erie County, New York·
4.0
(97) review
1 Museum Ct, Buffalo, NY 14216-3160
2
Inniskillin Wines
Niagara-on-the-Lake, Ontario·
4.5
(969) review
Many of those who appreciate and collect wine have discovered that a journey to the heart of wine country adds an indescribable dimension to the appreciation of the distinctiveness of each fine wine. In that spirit, Inniskillin invites you to fully experience our full VQA portfolio in Niagara-on-the-Lake. Experience firsthand the full range of our premium wines while enjoying spectacular sights, regional culinary specialties and outstanding hospitality in one of Canada's great natural treasures, the Niagara Peninsula. We look forward to toasting your arrival!
1499 Line 3, Niagara-on-the-Lake, Ontario L0S 1J0 Canada
3
Erie Bayfront Convention Center
Erie, Pennsylvania·
4.5
(97) review
1 Sassafras Pier, Erie, PA 16507-2011
4
Presque Isle Downs & Casino
Erie, Pennsylvania·
3.5
(981) review
Presque Isle Downs & Casino is your best bet for gaming excitement! With over 1,500 of the hottest slots, you'll find a thrilling new game to spin every time you play. Prefer tables? You're in luck! Come try your hand at any of our over 30 thrilling table games. Like to bet on sports? Get in the game at our TwinSpires Sportsbook! With convenient sports betting kiosks, wagering is quick and easy so you'll never miss a minute of the action. Plus, catch seasonal live thoroughbred horse racing at our track! While you're here be sure to sign up for our Players Club. All new members get up to $2,500 free slot play or $25 in guaranteed match play right out of the gate! It's fast and free to join. Every time you play with your Players Club card you'll earn valuable reward points that qualify you to enjoy members-only promotions, perks, exclusive offers and much more! Presque Isle Downs & Casino is located in Erie, PA, just off of I-90 at Exit 27. Gambling Problem? Call 1-800 GAMBLER.
8199 Perry Hwy, Erie, PA 16509-6640
5
Cathedral of Learning
Pittsburgh, Pennsylvania·
4.5
(979) review
4200 5th Ave., Pittsburgh, PA 15260
6
Point State Park
Pittsburgh, Pennsylvania·
4.5
(951) review
Serving as a key strategic spot during the French and Indian War, this National Historic Landmark and park offer stunning views of the city and a variety of outdoor recreation.
601 Commonwealth Pl Bldg A, Pittsburgh, PA 15222
7
Iron Heart Winery
Allisonia, Virginia·
4.0
(7) review
3742 Boone Furnace Rd, Allisonia, VA 24347-4001
8
Grand 18-Winston-Salem
Winston Salem, North Carolina·
4.0
(72) review
5601 University Pkwy, Winston Salem, NC 27105-1313
9
Lam Museum of Anthropology, Wake Forest University
Winston Salem, North Carolina·
4.0
(9) review
Discover North Carolina's only museum dedicated to the study of global cultures. Explore stories of humanity, from ancient archaeological sites to the celebrations and struggles of today. Learn about peoples around the world through their everyday and ceremonial objects, and visual arts. Changing exhibits highlight the Museum's collections of nearly 30,000 archaeological and ethnographic artifacts from more than 350 cultures and 90 countries. Admission is free.
Palmer Hall, Carroll Weathers Drive, Winston Salem, NC 27109
10
Salem Lake
Winston Salem, North Carolina·
4.5
(97) review
1001 Salem Lake Rd, Winston Salem, NC 27107-1571
11
Possum Trot Golf Club
Myrtle Beach, South Carolina·
3.5
(93) review
Recommended course noted for exceptional service and playing conditions.
Possum Trot Road, Myrtle Beach, SC 29582
12
Myrtle Beach National
Myrtle Beach, South Carolina·
3.5
(7) review
4900 National Dr, Myrtle Beach, SC 29579-7212
13
Tanger Outlets Myrtle Beach Hwy 17
Myrtle Beach, South Carolina·
4.0
(929) review
Find great savings on merchandise from your favorite designer and name-brands direct from the manufacturer at stores like: Polo Ralph Lauren, Old Navy, Calvin Klein, Gap, Banana Republic, Ann Taylor, Kate Spade, Lucky Brand Jeans, Coach, Tommy Hilfiger and many more. Before you travel, check out the Tanger Outlet website to find the latest Coupons & Sales Offers for Tanger Outlets in Myrtle Beach. Or, when you arrive at the outlets, make your first stop Shopper Services to learn about the benefits of joining TangerClub (Tanger Club information is also available online). In Shopper Services you can purchase a coupon book full of great savings or if you are already a TangerClub member pick up a coupon book for free! Think Outlets, Think Tanger.
10835 Kings Rd, Myrtle Beach, SC 29572-6076
14
Magoo's Sports & Spirits
Myrtle Beach, South Carolina·
3.0
(7) review
Magoo's Sports & Spirits has been a Myrtle Beach neighborhood sports bar since 1995. Magoo's features an expansive mahogany central bar and plays all sports, all the time, from 24 televisions - not to mention steel and electronic darts, pool, and a host of games. Famous for the best chicken wings in Myrtle Beach and out-of-this-world burgers, Magoo expanded the menu for their new location to include paninis, seafood baskets, and sweet potato fries. Join us for our weekly events! -Taco Tuesday: Get two tacos for $5. Tequila and vodka drinks are $2.50 after 9 pm -Trivia Thursday: Starts at 6 pm. Prizes for winner! -Friday Soft Tip Dart Tournament: Sign-ups start at 6 pm and darts fly at 7:30 pm
3308 Waccamaw Blvd, Myrtle Beach, SC 29579-9464
15
The Simpsons in 4D
Myrtle Beach, South Carolina·
4.0
(97) review
Established in 2018. The Simpsons in 4D is a fully-themed cinematic attraction located at Broadway at the Beach in Myrtle Beach, South Carolina. Follow @Si4D.Simpsons4D on Instagram and Facebook for updates! The Simpsons in 4D delivers a slice of Springfield with the famous Aztec Theater and Kwik-E-Mart from the groundbreaking television show. The Aztec Theater features a themed lobby experience and a 4D Experience starring Homer and his family. This exciting animated special effects experience with 4D motion seats follows The Simpsons on a fun-filled immersive adventure. Shows run every 15 minutes. The Aztec Theater is a ticketed experience that also includes a souvenir red carpet photo with The Simpsons. Next door, guests can explore and shop at the iconic Kwik-E-Mart The convenience store has been brought to life with select products, including Buzz Soda, Lard Lad Donuts and six show-inspired Squishee flavors, as well as a wide array of custom The Simpsons branded merchandise.
1199 Celebrity Cir Broadway at the Beach, Myrtle Beach, SC 29577
16
X Gym Sports Mall
Myrtle Beach, South Carolina·
4.0
(7) review
568 George Bishop Pkwy near 501 and 17 Highway, Myrtle Beach, SC 29579-7339

CHECKLIST

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FAQ
Frequently Asked Questions
What's the driving distance between Buffalo and Myrtle Beach?
The distance is 823 miles
What's the travel time between Buffalo and Myrtle Beach?
The driving time can vary depending on traffic conditions, but it is typically 16h 9m mins in normal traffic
What are some of the best cities to visit between Buffalo and Myrtle Beach?
Some popular stops include
Are there any cool sights or attractions I shouldn't miss on my drive to Myrtle Beach?
There are plenty! Here are some stops you shouldn’t miss on your way to Myrtle Beach
What’s the weather like in Myrtle Beach?
The weather in Myrtle Beach is generally mild year-round, with warm, dry summers and cool, wet winters. See the links below for more information
Weather in Myrtle Beach in January
Weather in Myrtle Beach in February
Weather in Myrtle Beach in March
Weather in Myrtle Beach in April
Weather in Myrtle Beach in May
Weather in Myrtle Beach in June
Weather in Myrtle Beach in July
Weather in Myrtle Beach in August
Weather in Myrtle Beach in September
Weather in Myrtle Beach in October
Weather in Myrtle Beach in November
Weather in Myrtle Beach in December
Interested in a detailed plan for your time in Myrtle Beach?
Plan your dream Myrtle Beach trip with our daily itineraries featuring must-see attractions! See them here!
A 1-day itinerary in Myrtle Beach
A 2-day itinerary in Myrtle Beach
A 3-day itinerary in Myrtle Beach
A 4-day itinerary in Myrtle Beach
A 5-day itinerary in Myrtle Beach
A 6-day itinerary in Myrtle Beach
Where else can I travel to if I'm starting my trip in Buffalo?
We have a lot of great trip options for Buffalo! See the links below for all the itineraries we created for you