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By Huuk Team

Road trip from Buffalo to Knoxville

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ITINERARY

12h 58m687 miles28 stops
1
Seneca Buffalo Creek Casino
1 Fulton St, Buffalo, NY 14204-2248
2
The Buffalo History Museum
1 Museum Ct, Buffalo, NY 14216-3160
3
Inniskillin Wines
1499 Line 3, Niagara-on-the-Lake, Ontario L0S 1J0 Canada
Many of those who appreciate and collect wine have discovered that a journey to the heart of wine country adds an indescribable dimension to the appreciation of the distinctiveness of each fine wine. In that spirit, Inniskillin invites you to fully experience our full VQA portfolio in Niagara-on-the-Lake. Experience firsthand the full range of our premium wines while enjoying spectacular sights, regional culinary specialties and outstanding hospitality in one of Canada's great natural treasures, the Niagara Peninsula. We look forward to toasting your arrival!
4
Kew Vineyards Estate Winery
4696 King St, Beamsville, Lincoln, Ontario L0R 1B1 Canada
5
Erie Bayfront Convention Center
1 Sassafras Pier, Erie, PA 16507-2011
6
Presque Isle Downs & Casino
8199 Perry Hwy, Erie, PA 16509-6640
Presque Isle Downs & Casino is your best bet for gaming excitement! With over 1,500 of the hottest slots, you'll find a thrilling new game to spin every time you play. Prefer tables? You're in luck! Come try your hand at any of our over 30 thrilling table games. Like to bet on sports? Get in the game at our TwinSpires Sportsbook! With convenient sports betting kiosks, wagering is quick and easy so you'll never miss a minute of the action. Plus, catch seasonal live thoroughbred horse racing at our track! While you're here be sure to sign up for our Players Club. All new members get up to $2,500 free slot play or $25 in guaranteed match play right out of the gate! It's fast and free to join. Every time you play with your Players Club card you'll earn valuable reward points that qualify you to enjoy members-only promotions, perks, exclusive offers and much more! Presque Isle Downs & Casino is located in Erie, PA, just off of I-90 at Exit 27. Gambling Problem? Call 1-800 GAMBLER.
7
Museum of Contemporary Art Cleveland
11400 Euclid Ave, Cleveland, OH 44106-3926
8
Rock & Roll Hall of Fame
1100 Rock and Roll Blvd Main Terminal, Cleveland, OH 44114-1023
Headquartered in a boldly designed building on Lake Erie's shore, The Rock and Roll Hall of Fame is a 150,000-square-foot museum featuring ever-changing exhibits documenting the history of rock and roll, from Elvis to our days. You’ll see hundreds of original artifacts, from Jimi Hendrix outfits to The Beatles’ handwritten lyrics. Experience the excitement of a Rock Hall induction night at the Power of Rock Experience or have your very own jam session at the Garage. You can also watch a concert while you're here, so check out the Rock Hall’s schedule and plan ahead. – Tripadvisor
9
Federal Reserve Bank of Cleveland: Education and Learning Center
1455 E 6th St, Cleveland, OH 44114-2517
Ever wonder how money works or what the Federal Reserve Bank of Cleveland does as part of the central bank of the US? Visit our Education and Learning Center featuring more than 25 fun, hands-on exhibits that answer these questions and more! We have interactive games, visual exhibits, creative stations, and illuminating films that explain everything about money you can think of, from how we use it, to why it looks the way it looks. Come see our historic lobby, take pictures with our money tree, trade coconuts on Barter Island, identify counterfeit bills, and even make your own money! All this in the heart of Cleveland, just steps away from downtown attractions. Admission is free and photos are welcome.
10
Lock 3
200 S Main St, Akron, OH 44308-1315
11
Tabletop Game Cafe
4316 N High St, Columbus, OH 43214-2610
A game cafe in Clintonville, Columbus. Featuring a large tabletop game library and serving coffee, beer, empanadas and a wide range of snacks. If you’re using our space, we ask that you not bring outside food and order a minimum of $6. Enjoy our game library - loosely ordered from more complex games to games for young kids. Open early if you're just looking for a local coffee shop to hang out.
12
Governor's Residence
358 N Parkview Ave, Columbus, OH 43209-1439
13
Ohio Stadium
411 Woody Hayes Dr,, Columbus, OH 43210-1104
14
Chadwick Arboretum
2120 Fyffe Rd Ohio State University, Columbus, OH 43210-1010
15
Kelton House Museum & Garden
586 E Town St, Columbus, OH 43215-4802
Experience urban life and the decorative arts, as they existed in the second half of the 19th century, through the collection of the Sophia and Fernando Cortez Kelton family. Learn about the Underground Railroad and the people that bring the history to life.
16
Redbird Hollow Preserve
5963 Given Rd # 6005, Cincinnati, OH 45243-3316
17
Ault Park
3600 Observatory Ave, Cincinnati, OH 45208-2549
18
Greater Cincinnati Police Museum
308 Reading Rd 2nd Floor, Cincinnati, OH 45202-1345
The Greater Cincinnati Police Museum is the only regional police museum in the country. We cover all Federal, State, Local, and Private agencies in South West Ohio, Northern Kentucky, and Eastern Indiana, the safest place in the country to live.
19
The Public Library of Cincinnati and Hamilton County
800 Vine St, Cincinnati, Cincinnati, OH 45202-2009
The Public Library of Cincinnati and Hamilton County (PLCH) is a public library system in the United States. In addition to its main library location in downtown Cincinnati, Ohio, PLCH operates 41 regional and branch locations throughout Hamilton County. As of 2012, the PLCH's collection holds about nine million volumes, making it the 13th-largest library in the U.S
20
Lexington Brewing & Distilling Co.
401 Cross St, Lexington, KY 40508-2806
The first era of the Lexington Brewing Co. began in the 1890s and came to a halt during Prohibition, changing ownership several times in the decades that followed. By the time Pearse Lyons and his son, Mark, explored the brewery in 1999, it was a dilapidated shell of what it had once been. However, Pearse was a visionary and entrepreneur and saw only what it could be. Spurred by a passion for brewing and distilling that courses through the Lyons family lineage of Irish coopers, Pearse revived Lexington Brewing Co. and restored a craft beer tradition that dates back to the 1700s. Pearse continued to dream big as he set his sights on distilling — a natural progression given his background in fermentation, his family’s heritage and Kentucky’s bourbon tradition. Two copper pot stills that were commissioned from Scotland arrived at Lexington Brewing Co. in 2008. In 2012, Town Branch Distillery opened, first new distillery to be built in Lexington, Kentucky, in more than 100 yrs.
21
Fayette Mall
3401 Nicholasville Rd, Lexington, KY 40503-3611
Fayette Mall is located at the intersection of Nicholasville Road and Reynolds Road. The mall is central Kentucky’s premier shopping destination with over 170 retailer and dining options including The Disney Store, H&M, Michael Kors, Sephora and The Cheesecake Factory. Fayette Mall also features a children’s play area located in Center Court. Mobile device charging stations can be found in the Food Court. WiFi is available at Starbucks, Dillard’s and Dick’s Sporting Goods. Customer Service Center is located inside the front entrance next to P.F. Chang’s. Visit shopfayette-mall.com for more information including a complete list of retailers, restaurants, entertainment options and a mall map.
22
Waveland State Historic Site
225 Waveland Museum Ln, Lexington, KY 40514-1618
Experience 19th century plantation life at this historic compound where you can tour the mansion or "big house," see quarters where slaves lived, visit a smokehouse and other elements of daily life in the Old South.
23
Muse Knoxville
516 N Beaman St, Knoxville, TN 37914-4410
Muse Knoxville is a children’s Science, Technology, Engineering, Arts, & Math (STEAM) museum located in Chilhowee Park. Our programs in the museum, in schools across East Tennessee, & throughout Knoxville bring STEM, the arts, health & wellness, & emergent literacy to life in the minds of children. We inspire & empower ALL children through transformative learning experiences through a variety of hands-on and inquiry-based, exhibits and Outreach programs for children aged 6 mos. to 10 y/o. *Museum Play - Indoor educational learning & play spaces, a full-dome planetarium, outdoor learning spaces & a playground! *Field Trips - Bring your class, homeschool, daycare or youth group for a day of fun! *Parties/Events - Choose from a variety of packages to celebrate your special day with us. *Planetarium - We house East Tennessee's only public-access planetarium with shows that rotate every hour!
24
Knoxville Botanical Garden
2743 Wimpole Ave, Knoxville, TN 37914-5958
25
The Mill and Mine
227 W Depot Ave, Knoxville, TN 37917-7521
26
Krutch Park
504 Market St, Knoxville, TN 37902-2107
27
Peter Kern Library
407 Union Ave, Knoxville, TN 37902-2112
Hidden inside the historic Kern Building, behind The Oliver Hotel lobby, is Knoxville’s one and only speakeasy, The Peter Kern Library. Once a well-kept secret, the bar is now a beloved institution. The dark wood, fireplace, rows of books, and cocktails named after literary characters create a warm and cozy atmosphere where time seems to stop.
28
Cathedral of the Most Sacred Heart of Jesus
711 S Northshore Dr, Knoxville, TN 37919-7593
Customize this Trip

OVERVIEW

1
Start:Seneca Buffalo Creek Casino
Buffalo, Erie County, New York·
3.0
(95) review
1 Fulton St, Buffalo, NY 14204-2248
2
The Buffalo History Museum
Buffalo, Erie County, New York·
4.0
(97) review
1 Museum Ct, Buffalo, NY 14216-3160
3
Inniskillin Wines
Niagara-on-the-Lake, Ontario·
4.5
(969) review
Many of those who appreciate and collect wine have discovered that a journey to the heart of wine country adds an indescribable dimension to the appreciation of the distinctiveness of each fine wine. In that spirit, Inniskillin invites you to fully experience our full VQA portfolio in Niagara-on-the-Lake. Experience firsthand the full range of our premium wines while enjoying spectacular sights, regional culinary specialties and outstanding hospitality in one of Canada's great natural treasures, the Niagara Peninsula. We look forward to toasting your arrival!
1499 Line 3, Niagara-on-the-Lake, Ontario L0S 1J0 Canada
4
Kew Vineyards Estate Winery
Beamsville, Lincoln, Ontario·
4.5
(96) review
4696 King St, Beamsville, Lincoln, Ontario L0R 1B1 Canada
5
Erie Bayfront Convention Center
Erie, Pennsylvania·
4.5
(97) review
1 Sassafras Pier, Erie, PA 16507-2011
6
Presque Isle Downs & Casino
Erie, Pennsylvania·
3.5
(981) review
Presque Isle Downs & Casino is your best bet for gaming excitement! With over 1,500 of the hottest slots, you'll find a thrilling new game to spin every time you play. Prefer tables? You're in luck! Come try your hand at any of our over 30 thrilling table games. Like to bet on sports? Get in the game at our TwinSpires Sportsbook! With convenient sports betting kiosks, wagering is quick and easy so you'll never miss a minute of the action. Plus, catch seasonal live thoroughbred horse racing at our track! While you're here be sure to sign up for our Players Club. All new members get up to $2,500 free slot play or $25 in guaranteed match play right out of the gate! It's fast and free to join. Every time you play with your Players Club card you'll earn valuable reward points that qualify you to enjoy members-only promotions, perks, exclusive offers and much more! Presque Isle Downs & Casino is located in Erie, PA, just off of I-90 at Exit 27. Gambling Problem? Call 1-800 GAMBLER.
8199 Perry Hwy, Erie, PA 16509-6640
7
Museum of Contemporary Art Cleveland
Cleveland, Ohio·
3.5
(93) review
11400 Euclid Ave, Cleveland, OH 44106-3926
8
Rock & Roll Hall of Fame
Cleveland, Ohio·
4.5
(9964) review
Headquartered in a boldly designed building on Lake Erie's shore, The Rock and Roll Hall of Fame is a 150,000-square-foot museum featuring ever-changing exhibits documenting the history of rock and roll, from Elvis to our days. You’ll see hundreds of original artifacts, from Jimi Hendrix outfits to The Beatles’ handwritten lyrics. Experience the excitement of a Rock Hall induction night at the Power of Rock Experience or have your very own jam session at the Garage. You can also watch a concert while you're here, so check out the Rock Hall’s schedule and plan ahead. – Tripadvisor
1100 Rock and Roll Blvd Main Terminal, Cleveland, OH 44114-1023
9
Federal Reserve Bank of Cleveland: Education and Learning Center
Cleveland, Ohio·
4.5
(95) review
Ever wonder how money works or what the Federal Reserve Bank of Cleveland does as part of the central bank of the US? Visit our Education and Learning Center featuring more than 25 fun, hands-on exhibits that answer these questions and more! We have interactive games, visual exhibits, creative stations, and illuminating films that explain everything about money you can think of, from how we use it, to why it looks the way it looks. Come see our historic lobby, take pictures with our money tree, trade coconuts on Barter Island, identify counterfeit bills, and even make your own money! All this in the heart of Cleveland, just steps away from downtown attractions. Admission is free and photos are welcome.
1455 E 6th St, Cleveland, OH 44114-2517
10
Lock 3
Akron, Ohio·
4.5
(98) review
200 S Main St, Akron, OH 44308-1315
11
Tabletop Game Cafe
Columbus, Ohio·
5.0
(9) review
A game cafe in Clintonville, Columbus. Featuring a large tabletop game library and serving coffee, beer, empanadas and a wide range of snacks. If you’re using our space, we ask that you not bring outside food and order a minimum of $6. Enjoy our game library - loosely ordered from more complex games to games for young kids. Open early if you're just looking for a local coffee shop to hang out.
4316 N High St, Columbus, OH 43214-2610
12
Governor's Residence
Columbus, Ohio·
4.5
(9) review
358 N Parkview Ave, Columbus, OH 43209-1439
13
Ohio Stadium
Columbus, Ohio·
4.5
(979) review
411 Woody Hayes Dr,, Columbus, OH 43210-1104
14
Chadwick Arboretum
Columbus, Ohio·
4.0
(9) review
2120 Fyffe Rd Ohio State University, Columbus, OH 43210-1010
15
Kelton House Museum & Garden
Columbus, Ohio·
4.5
(96) review
Experience urban life and the decorative arts, as they existed in the second half of the 19th century, through the collection of the Sophia and Fernando Cortez Kelton family. Learn about the Underground Railroad and the people that bring the history to life.
586 E Town St, Columbus, OH 43215-4802
16
Redbird Hollow Preserve
Cincinnati, Ohio·
4.5
(9) review
5963 Given Rd # 6005, Cincinnati, OH 45243-3316
17
Ault Park
Cincinnati, Ohio·
5.0
(95) review
3600 Observatory Ave, Cincinnati, OH 45208-2549
18
Greater Cincinnati Police Museum
Cincinnati, Ohio·
5.0
(95) review
The Greater Cincinnati Police Museum is the only regional police museum in the country. We cover all Federal, State, Local, and Private agencies in South West Ohio, Northern Kentucky, and Eastern Indiana, the safest place in the country to live.
308 Reading Rd 2nd Floor, Cincinnati, OH 45202-1345
19
The Public Library of Cincinnati and Hamilton County
Cincinnati, Ohio·
4.0
(9) review
The Public Library of Cincinnati and Hamilton County (PLCH) is a public library system in the United States. In addition to its main library location in downtown Cincinnati, Ohio, PLCH operates 41 regional and branch locations throughout Hamilton County. As of 2012, the PLCH's collection holds about nine million volumes, making it the 13th-largest library in the U.S
800 Vine St, Cincinnati, Cincinnati, OH 45202-2009
20
Lexington Brewing & Distilling Co.
Lexington, Kentucky·
4.5
(984) review
The first era of the Lexington Brewing Co. began in the 1890s and came to a halt during Prohibition, changing ownership several times in the decades that followed. By the time Pearse Lyons and his son, Mark, explored the brewery in 1999, it was a dilapidated shell of what it had once been. However, Pearse was a visionary and entrepreneur and saw only what it could be. Spurred by a passion for brewing and distilling that courses through the Lyons family lineage of Irish coopers, Pearse revived Lexington Brewing Co. and restored a craft beer tradition that dates back to the 1700s. Pearse continued to dream big as he set his sights on distilling — a natural progression given his background in fermentation, his family’s heritage and Kentucky’s bourbon tradition. Two copper pot stills that were commissioned from Scotland arrived at Lexington Brewing Co. in 2008. In 2012, Town Branch Distillery opened, first new distillery to be built in Lexington, Kentucky, in more than 100 yrs.
401 Cross St, Lexington, KY 40508-2806
21
Fayette Mall
Lexington, Kentucky·
4.5
(91) review
Fayette Mall is located at the intersection of Nicholasville Road and Reynolds Road. The mall is central Kentucky’s premier shopping destination with over 170 retailer and dining options including The Disney Store, H&M, Michael Kors, Sephora and The Cheesecake Factory. Fayette Mall also features a children’s play area located in Center Court. Mobile device charging stations can be found in the Food Court. WiFi is available at Starbucks, Dillard’s and Dick’s Sporting Goods. Customer Service Center is located inside the front entrance next to P.F. Chang’s. Visit shopfayette-mall.com for more information including a complete list of retailers, restaurants, entertainment options and a mall map.
3401 Nicholasville Rd, Lexington, KY 40503-3611
22
Waveland State Historic Site
Lexington, Kentucky·
4.5
(97) review
Experience 19th century plantation life at this historic compound where you can tour the mansion or "big house," see quarters where slaves lived, visit a smokehouse and other elements of daily life in the Old South.
225 Waveland Museum Ln, Lexington, KY 40514-1618
23
Muse Knoxville
Knoxville, Tennessee·
4.0
(91) review
Muse Knoxville is a children’s Science, Technology, Engineering, Arts, & Math (STEAM) museum located in Chilhowee Park. Our programs in the museum, in schools across East Tennessee, & throughout Knoxville bring STEM, the arts, health & wellness, & emergent literacy to life in the minds of children. We inspire & empower ALL children through transformative learning experiences through a variety of hands-on and inquiry-based, exhibits and Outreach programs for children aged 6 mos. to 10 y/o. *Museum Play - Indoor educational learning & play spaces, a full-dome planetarium, outdoor learning spaces & a playground! *Field Trips - Bring your class, homeschool, daycare or youth group for a day of fun! *Parties/Events - Choose from a variety of packages to celebrate your special day with us. *Planetarium - We house East Tennessee's only public-access planetarium with shows that rotate every hour!
516 N Beaman St, Knoxville, TN 37914-4410
24
Knoxville Botanical Garden
Knoxville, Tennessee·
3.5
(97) review
2743 Wimpole Ave, Knoxville, TN 37914-5958
25
The Mill and Mine
Knoxville, Tennessee·
5.0
(9) review
227 W Depot Ave, Knoxville, TN 37917-7521
26
Krutch Park
Knoxville, Tennessee·
4.5
(90) review
504 Market St, Knoxville, TN 37902-2107
27
Peter Kern Library
Knoxville, Tennessee·
4.0
(99) review
Hidden inside the historic Kern Building, behind The Oliver Hotel lobby, is Knoxville’s one and only speakeasy, The Peter Kern Library. Once a well-kept secret, the bar is now a beloved institution. The dark wood, fireplace, rows of books, and cocktails named after literary characters create a warm and cozy atmosphere where time seems to stop.
407 Union Ave, Knoxville, TN 37902-2112
28
Cathedral of the Most Sacred Heart of Jesus
Knoxville, Tennessee·
4.5
(9) review
711 S Northshore Dr, Knoxville, TN 37919-7593

CHECKLIST

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FAQ
Frequently Asked Questions
What's the driving distance between Buffalo and Knoxville?
The distance is 687 miles
What's the travel time between Buffalo and Knoxville?
The driving time can vary depending on traffic conditions, but it is typically 12h 58m mins in normal traffic
What are some of the best cities to visit between Buffalo and Knoxville?
Some popular stops include
Are there any cool sights or attractions I shouldn't miss on my drive to Knoxville?
There are plenty! Here are some stops you shouldn’t miss on your way to Knoxville
What’s the weather like in Knoxville?
The weather in Knoxville is generally mild year-round, with warm, dry summers and cool, wet winters. See the links below for more information
Weather in Knoxville in January
Weather in Knoxville in February
Weather in Knoxville in March
Weather in Knoxville in April
Weather in Knoxville in May
Weather in Knoxville in June
Weather in Knoxville in July
Weather in Knoxville in August
Weather in Knoxville in September
Weather in Knoxville in October
Weather in Knoxville in November
Weather in Knoxville in December
Interested in a detailed plan for your time in Knoxville?
Plan your dream Knoxville trip with our daily itineraries featuring must-see attractions! See them here!
A 1-day itinerary in Knoxville
A 2-day itinerary in Knoxville
A 3-day itinerary in Knoxville
A 4-day itinerary in Knoxville
A 5-day itinerary in Knoxville
A 6-day itinerary in Knoxville
Where else can I travel to if I'm starting my trip in Buffalo?
We have a lot of great trip options for Buffalo! See the links below for all the itineraries we created for you