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By Huuk Team

Road trip from Buffalo to Greenville

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ITINERARY

14h 30m752 miles18 stops
1
The Buffalo History Museum
1 Museum Ct, Buffalo, NY 14216-3160
2
Inniskillin Wines
1499 Line 3, Niagara-on-the-Lake, Ontario L0S 1J0 Canada
Many of those who appreciate and collect wine have discovered that a journey to the heart of wine country adds an indescribable dimension to the appreciation of the distinctiveness of each fine wine. In that spirit, Inniskillin invites you to fully experience our full VQA portfolio in Niagara-on-the-Lake. Experience firsthand the full range of our premium wines while enjoying spectacular sights, regional culinary specialties and outstanding hospitality in one of Canada's great natural treasures, the Niagara Peninsula. We look forward to toasting your arrival!
3
Erie Bayfront Convention Center
1 Sassafras Pier, Erie, PA 16507-2011
4
Presque Isle Downs & Casino
8199 Perry Hwy, Erie, PA 16509-6640
Presque Isle Downs & Casino is your best bet for gaming excitement! With over 1,500 of the hottest slots, you'll find a thrilling new game to spin every time you play. Prefer tables? You're in luck! Come try your hand at any of our over 30 thrilling table games. Like to bet on sports? Get in the game at our TwinSpires Sportsbook! With convenient sports betting kiosks, wagering is quick and easy so you'll never miss a minute of the action. Plus, catch seasonal live thoroughbred horse racing at our track! While you're here be sure to sign up for our Players Club. All new members get up to $2,500 free slot play or $25 in guaranteed match play right out of the gate! It's fast and free to join. Every time you play with your Players Club card you'll earn valuable reward points that qualify you to enjoy members-only promotions, perks, exclusive offers and much more! Presque Isle Downs & Casino is located in Erie, PA, just off of I-90 at Exit 27. Gambling Problem? Call 1-800 GAMBLER.
5
Allegheny Cemetery
4734 Butler St, Pittsburgh, PA 15201-2951
Instituted in 1844, this 300-acre cemetery is the final resting place of such notables as Lillian Russell, Stephen Foster and General John Neville.
6
Cathedral of Learning
4200 5th Ave., Pittsburgh, PA 15260
7
Point State Park
601 Commonwealth Pl Bldg A, Pittsburgh, PA 15222
Serving as a key strategic spot during the French and Indian War, this National Historic Landmark and park offer stunning views of the city and a variety of outdoor recreation.
8
Iron Heart Winery
3742 Boone Furnace Rd, Allisonia, VA 24347-4001
9
Historic Bethania, NC
5393 Ham Horton Lane Bethania, NC, Winston Salem, NC 27010
10
Total Escape
280 Charlois Blvd Ste. 200, Winston Salem, NC 27103-1508
Total Escape is Winston Salem's favorite escape room, and we're 100% family friendly (not scary!) From Mayan Temples to high security prisons, our escape rooms are designed to create fully immersive experiences with unique and challenging puzzles. With only one hour and one way out, will you have the critical thinking and observation skills you need to escape?
11
Juggheads Growlers & Pints
4843 Country Club Rd, Winston Salem, NC 27104-4503
12
Historic Rosedale
3427 N Tryon St, Charlotte, NC 28206-2052
Built in 1815, Historic Rosedale is a Federal style home surrounded by 9 acres of spectacular gardens and lush green space located just 3 miles north of Charlotte City Centre. Guided tours of the historic house are available every Friday 11:30am, and 1:00pm, and the last Saturday of the month at 11:30am and 1:00pm. Self-guided grounds only tours are available Wednesday - Friday from 10:00am to 2:30pm, (garden tours only does not include admission to historic house).
13
Wooden Robot Brewery
1440 S Tryon St Suite 110, Charlotte, NC 28203-4262
14
Bojangles' Coliseum
2700 E Independence Blvd, Charlotte, NC 28205-6925
Located in Charlotte, NC - Since 1955, Bojangles' Coliseum has hosted concerts, family shows, conferences, sports events, and Charlotte Checkers hockey.
15
Grove Arcade
1 Page Ave, Asheville, NC 28801-2382
Grove Arcade is a beautifully preserved historical building in the heart of Downtown Asheville that represents the heart and character of the town. It’s rich history and ornate architecture combined with its eclectic mix of shops and restaurants offer patrons a full-day immersion into Asheville lifestyle and culture.
16
Sugar Creek Brewing Company
215 Southside Dr, Charlotte, NC 28217-1727
Sugar Creek Brewing Co. Bringing Belgian-inspired beer to the Carolinas and beyond, Sugar Creek Brewing Company combines the watchful eye of a Trappist Monk with the technical precision of nuclear engineering to craft fresh, full-flavored beers that are immensely satisfying and intensely drinkable. Using unique combinations of aromatic yeast strains, domestic and imported hops and award-winning malt varietys, Sugar Creek infuses traditional recipes with modern tastes and techniques to create beer that nourishes both mind and body. Sugar Creek Tap Room Mon-Wed: 4pm - 9pm Thursday: 4pm - 10pm Friday: 2pm - 10pm Saturday: 11am- 10pm Sunday: 12pm - 8pm Tighten the ropes and raise the sails, the Sugar Creek Brewing Co. Tap room is where your exploration begins! We have constructed a large taproom and private event room and staffed it with kind, courteous and knowledgeable beertenders. On tap you will find all of our year-round beers as well as seasonal and small-batch releases. Beers are available by the glass, 4 oz. Tasting flights, and growler fills via our Pegas CrafTap growler filler. The taproom is open for exploration seven days a week! Sugar Creek Private Event Room Adjacent to our taproom is our 1700 sqft private event room, complete with a private outdoor patio, private bar, and overhead projector. Private events are available seven days a week, for parties as small as 15 people. In addition to offering a full range of our favorite beers, Sugar Creek is happy to provide food services or accommodate outside catering.
17
The Sleepy Poet Antiques Mall
4450 South Blvd, Charlotte, NC 28209-2673
18
Greenville Zoo
150 Cleveland Park Dr, Greenville, SC 29601-3147
Customize this Trip

OVERVIEW

1
Start:The Buffalo History Museum
Buffalo, Erie County, New York·
4.0
(97) review
1 Museum Ct, Buffalo, NY 14216-3160
2
Inniskillin Wines
Niagara-on-the-Lake, Ontario·
4.5
(969) review
Many of those who appreciate and collect wine have discovered that a journey to the heart of wine country adds an indescribable dimension to the appreciation of the distinctiveness of each fine wine. In that spirit, Inniskillin invites you to fully experience our full VQA portfolio in Niagara-on-the-Lake. Experience firsthand the full range of our premium wines while enjoying spectacular sights, regional culinary specialties and outstanding hospitality in one of Canada's great natural treasures, the Niagara Peninsula. We look forward to toasting your arrival!
1499 Line 3, Niagara-on-the-Lake, Ontario L0S 1J0 Canada
3
Erie Bayfront Convention Center
Erie, Pennsylvania·
4.5
(97) review
1 Sassafras Pier, Erie, PA 16507-2011
4
Presque Isle Downs & Casino
Erie, Pennsylvania·
3.5
(981) review
Presque Isle Downs & Casino is your best bet for gaming excitement! With over 1,500 of the hottest slots, you'll find a thrilling new game to spin every time you play. Prefer tables? You're in luck! Come try your hand at any of our over 30 thrilling table games. Like to bet on sports? Get in the game at our TwinSpires Sportsbook! With convenient sports betting kiosks, wagering is quick and easy so you'll never miss a minute of the action. Plus, catch seasonal live thoroughbred horse racing at our track! While you're here be sure to sign up for our Players Club. All new members get up to $2,500 free slot play or $25 in guaranteed match play right out of the gate! It's fast and free to join. Every time you play with your Players Club card you'll earn valuable reward points that qualify you to enjoy members-only promotions, perks, exclusive offers and much more! Presque Isle Downs & Casino is located in Erie, PA, just off of I-90 at Exit 27. Gambling Problem? Call 1-800 GAMBLER.
8199 Perry Hwy, Erie, PA 16509-6640
5
Allegheny Cemetery
Pittsburgh, Pennsylvania·
4.5
(94) review
Instituted in 1844, this 300-acre cemetery is the final resting place of such notables as Lillian Russell, Stephen Foster and General John Neville.
4734 Butler St, Pittsburgh, PA 15201-2951
6
Cathedral of Learning
Pittsburgh, Pennsylvania·
4.5
(979) review
4200 5th Ave., Pittsburgh, PA 15260
7
Point State Park
Pittsburgh, Pennsylvania·
4.5
(951) review
Serving as a key strategic spot during the French and Indian War, this National Historic Landmark and park offer stunning views of the city and a variety of outdoor recreation.
601 Commonwealth Pl Bldg A, Pittsburgh, PA 15222
8
Iron Heart Winery
Allisonia, Virginia·
4.0
(7) review
3742 Boone Furnace Rd, Allisonia, VA 24347-4001
9
Historic Bethania, NC
Winston Salem, North Carolina·
4.0
(46) review
5393 Ham Horton Lane Bethania, NC, Winston Salem, NC 27010
10
Total Escape
Winston Salem, North Carolina·
5.0
(42) review
Total Escape is Winston Salem's favorite escape room, and we're 100% family friendly (not scary!) From Mayan Temples to high security prisons, our escape rooms are designed to create fully immersive experiences with unique and challenging puzzles. With only one hour and one way out, will you have the critical thinking and observation skills you need to escape?
280 Charlois Blvd Ste. 200, Winston Salem, NC 27103-1508
11
Juggheads Growlers & Pints
Winston Salem, North Carolina·
5.0
(6) review
4843 Country Club Rd, Winston Salem, NC 27104-4503
12
Historic Rosedale
Charlotte, North Carolina·
4.5
(93) review
Built in 1815, Historic Rosedale is a Federal style home surrounded by 9 acres of spectacular gardens and lush green space located just 3 miles north of Charlotte City Centre. Guided tours of the historic house are available every Friday 11:30am, and 1:00pm, and the last Saturday of the month at 11:30am and 1:00pm. Self-guided grounds only tours are available Wednesday - Friday from 10:00am to 2:30pm, (garden tours only does not include admission to historic house).
3427 N Tryon St, Charlotte, NC 28206-2052
13
Wooden Robot Brewery
Charlotte, North Carolina·
4.5
(97) review
1440 S Tryon St Suite 110, Charlotte, NC 28203-4262
14
Bojangles' Coliseum
Charlotte, North Carolina·
4.0
(98) review
Located in Charlotte, NC - Since 1955, Bojangles' Coliseum has hosted concerts, family shows, conferences, sports events, and Charlotte Checkers hockey.
2700 E Independence Blvd, Charlotte, NC 28205-6925
15
Grove Arcade
Asheville, North Carolina·
4.0
(987) review
Grove Arcade is a beautifully preserved historical building in the heart of Downtown Asheville that represents the heart and character of the town. It’s rich history and ornate architecture combined with its eclectic mix of shops and restaurants offer patrons a full-day immersion into Asheville lifestyle and culture.
1 Page Ave, Asheville, NC 28801-2382
16
Sugar Creek Brewing Company
Charlotte, North Carolina·
4.5
(98) review
Sugar Creek Brewing Co. Bringing Belgian-inspired beer to the Carolinas and beyond, Sugar Creek Brewing Company combines the watchful eye of a Trappist Monk with the technical precision of nuclear engineering to craft fresh, full-flavored beers that are immensely satisfying and intensely drinkable. Using unique combinations of aromatic yeast strains, domestic and imported hops and award-winning malt varietys, Sugar Creek infuses traditional recipes with modern tastes and techniques to create beer that nourishes both mind and body. Sugar Creek Tap Room Mon-Wed: 4pm - 9pm Thursday: 4pm - 10pm Friday: 2pm - 10pm Saturday: 11am- 10pm Sunday: 12pm - 8pm Tighten the ropes and raise the sails, the Sugar Creek Brewing Co. Tap room is where your exploration begins! We have constructed a large taproom and private event room and staffed it with kind, courteous and knowledgeable beertenders. On tap you will find all of our year-round beers as well as seasonal and small-batch releases. Beers are available by the glass, 4 oz. Tasting flights, and growler fills via our Pegas CrafTap growler filler. The taproom is open for exploration seven days a week! Sugar Creek Private Event Room Adjacent to our taproom is our 1700 sqft private event room, complete with a private outdoor patio, private bar, and overhead projector. Private events are available seven days a week, for parties as small as 15 people. In addition to offering a full range of our favorite beers, Sugar Creek is happy to provide food services or accommodate outside catering.
215 Southside Dr, Charlotte, NC 28217-1727
17
The Sleepy Poet Antiques Mall
Charlotte, North Carolina·
4.5
(93) review
4450 South Blvd, Charlotte, NC 28209-2673
18
Greenville Zoo
Greenville, South Carolina·
4.0
(996) review
150 Cleveland Park Dr, Greenville, SC 29601-3147

CHECKLIST

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FAQ
Frequently Asked Questions
What's the driving distance between Buffalo and Greenville?
The distance is 752 miles
What's the travel time between Buffalo and Greenville?
The driving time can vary depending on traffic conditions, but it is typically 14h 30m mins in normal traffic
What are some of the best cities to visit between Buffalo and Greenville?
Some popular stops include
Are there any cool sights or attractions I shouldn't miss on my drive to Greenville?
There are plenty! Here are some stops you shouldn’t miss on your way to Greenville
What’s the weather like in Greenville?
The weather in Greenville is generally mild year-round, with warm, dry summers and cool, wet winters. See the links below for more information
Weather in Greenville in January
Weather in Greenville in February
Weather in Greenville in March
Weather in Greenville in April
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Weather in Greenville in December
Interested in a detailed plan for your time in Greenville?
Plan your dream Greenville trip with our daily itineraries featuring must-see attractions! See them here!
A 1-day itinerary in Greenville
A 2-day itinerary in Greenville
A 3-day itinerary in Greenville
A 4-day itinerary in Greenville
A 5-day itinerary in Greenville
A 6-day itinerary in Greenville
Where else can I travel to if I'm starting my trip in Buffalo?
We have a lot of great trip options for Buffalo! See the links below for all the itineraries we created for you